![]() The straight dope on cholesterol – Part IX - Previously, across 8 parts of this series we’ve laid the groundwork to ask perhaps the most important question of all: What should you eat to have the greatest chance of delaying the arrival of cardiovascular disease? Before we get there, since this series has been longer and more detailed than any of us may have wanted, it is probably worth reviewing the summary points from the previous posts in this series (or you can just skip this and jump to the meat of this post). What we’ve learned so far. Cholesterol is “just” another fancy organic molecule in our body but with an interesting distinction: we eat it, we make it, we store it, and we excrete it – all in different amounts. The pool of cholesterol in our body is essential for life. It is not absorbed and is excreted by our gut (i. The reason this occurs is that CE not only has to be de- esterified, but it competes for absorption with the vastly larger amounts of UC supplied by the biliary route. Re- absorption of the cholesterol we synthesize in our body (i. That is, most of the cholesterol in our body was made by our body. The process of regulating cholesterol is very complex and multifaceted with multiple layers of control. You will discover that synthesis and absorption are very interrelated. Eating cholesterol has very little impact on the cholesterol levels in your body. This is a fact, not my opinion. Years ago the Canadian Guidelines removed the limitation of dietary cholesterol. The rest of the world, especially the United States, needs to catch up. Their cholesterol is trafficked back to the liver. The apo. A- I containing particles traffic cholesterol to steroidogenic tissues, adipocytes (a storage organ for cholesterol ester) and ultimately back to the liver, gut, or steroidogenic tissue. All lipoproteins are part of the human lipid transportation system and work harmoniously together to efficiently traffic lipids. ![]() As you are probably starting to appreciate, the trafficking pattern is highly complex and the lipoproteins constantly exchange their core and surface lipids. The measurement of cholesterol has undergone a dramatic evolution over the past 7. Currently, most people in the United States (and the world for that matter) undergo a “standard” lipid panel, which only directly measures TC, TG, and HDL- C. However, Lp(a) and apo. B containing lipoproteins play a role also, especially in the insulin resistant person. If you want to stop atherosclerosis, you must lower the LDL particle number. Period. At first glance it would seem that patients with smaller LDL particles are at greater risk for atherosclerosis than patients with large LDL particles, all things equal.“A particle is a particle is a particle.” If you don’t know the number, you don’t know the risk. ![]() With respect to laboratory medicine, two markers that have a high correlation with a given outcome are concordant – they equally predict the same outcome. However, when the two tests do not correlate with each other they are said to be discordant. LDL- P (or apo. B) is the best predictor of adverse cardiac events, which has been documented repeatedly in every major cardiovascular risk study. LDL- C is only a good predictor of adverse cardiac events when it is concordant with LDL- P; otherwise it is a poor predictor of risk. There is no way of determining which individual patient may have discordant LDL- C and LDL- P without measuring both markers. Discordance between LDL- C and LDL- P is even greater in populations with metabolic syndrome, including patients with diabetes. A Testosterone Therapy Alternative for Men with Low Testosterone Levels. Whether you are a 30, 50, 80 or even 110 year old man, having low testosterone levels. This post is dedicated to Anne who asked me a great question about cholesterol. It made me do what I had been meaning to do ever since I read Dr Malcolm Kendrick’s. By Vin Kutty on June 5, 2010 96 Comments. Lowering Triglycerides with Lovaza vs Fish Oil Supplements. Most fish oils are NOT the same as Lovaza. But some are! What is a low carb diet, really? When can a low carb diet be beneficial? Should everyone follow a low carb diet? Or, can a low carb diet ruin your health? Account Options. Sign in; Search settings; Web History. Nils July 12, 2012. Great post as always, thanks. However, I do think you might have overlooked one critical aspect of diet. The conversion of fructose to. We value excellent academic writing and strive to provide outstanding essay writing services each and every time you place an order. We write essays. Gluten is incredible for its ability to piss off a diverse spectrum of people: Folks who are giving it up for a diet, folks who say it’s stupid to give up gluten. It’s not the first time this experiment has been delayed, but it marks the end of the launch window which ran from May 31st through June 6th. JPY (Japanese Yen) - Latest News, Analysis and Forex. But, raising HDL- C with a drug isn’t going to fix the problem. Making this even more complex is that HDL functionality is likely as important, or even more important, than HDL- P, but no such tests exist to “measure” this. Did you say “delay?”That’s right. The question posed above did not ask how one could “prevent” or eliminate the risk cardiovascular disease, it asked how one could “delay” it. Maybe it’s because I’m a math geek, but such models just seem intuitive to me because I think of most things in life in terms of calculus, especially integrals, the “area under a curve.”. Only time will tell if this hypothesis ends up in that same graveyard, or changes the way we think about lipoproteins and atherosclerosis. The role of sugar in cardiovascular disease. Let’s start with what we know, then fill in the connections, with the goal of creating an eating strategy for those most interested in delaying the onset of cardiovascular disease. There are several short- term studies that have carefully examined the impact of sugar, specifically, on cardiovascular risk markers. If you don’t have access to this journal, you can read the study here in pre- publication form. Rather than repeat any of it here, I’ll highlight one study that I did not include in that lecture. However, the subjects were instructed to avoid starch and consume 5. There were no restrictions on fruits and vegetables, which may have accounted for the observation that not all subjects were ketotic during the 6- week intervention. Atkins’ diet could reduce body fat, most believed it was still very dangerous. Until then each of us has to make a decision several times every day about what we will and won’t put in our mouths.
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